Self-organization of domain structures by DNA-loop-extruding enzymes
نویسندگان
چکیده
منابع مشابه
Self-organization of domain structures by DNA-loop-extruding enzymes
The long chromosomal DNAs of cells are organized into loop domains much larger in size than individual DNA-binding enzymes, presenting the question of how formation of such structures is controlled. We present a model for generation of defined chromosomal loops, based on molecular machines consisting of two coupled and oppositely directed motile elements which extrude loops from the double heli...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2012
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gks925